WWDC Sells Out in 2 Hours, Leaving Many Devs Ticketless ? And Outraged

Tickets for Apple's Worldwide Developers Conference are coveted, command a hefty price tag, and sell out quickly. But this year, tickets sold so rapidly, and so early in the day, that many West Coast developers were left ticketless -- and feeling alienated by Apple.

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Beyonce Named People?s Most Beautiful Woman 2012

Beyonce Named People’s Most Beautiful Woman 2012

Motherhood must agree with singer Beyonce! She was named People’s World’s Most Beautiful Woman 2012. Beyonce, 30, told the magazine, “I feel more beautiful than [...]

Beyonce Named People’s Most Beautiful Woman 2012 Stupid Celebrities Gossip Stupid Celebrities Gossip News

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Flickr outs new Uploadr feature for image uploads: HTML5-based, drag-and-drop UI

If you'll recall, it was only a few weeks ago when Flickr announced Aviary was replacing the vanished Picnik as the main photo-editing tool on the site. Now, continuing its ongoing makeover, the Yahoo-owned image hosting service is introducing yet another feature. Uploadr, as it's very cleverly dubbed, is an HTML5 web apparatus, which Flickr says will make for a "completely new uploading experience." There's a few major attributes Uploadr brings to the table, including improvements in the speed department, a drag-and-drop UI and bigger file size limits for paid and free users. Flickr notes that folks will now see a boost in uploading speeds of up to 30 percent, while "some" international users may see a spike of somewhere between 50-60 percent. As for file sizes, the limits have been bumped to 50MB for Pro hogs and 30MB for those enjoying the freebies. Uploadr's set to be rolling out over the "next couple of weeks," and is currently offering browser support for Chrome, Safari and Firefox.

Flickr outs new Uploadr feature for image uploads: HTML5-based, drag-and-drop UI originally appeared on Engadget on Wed, 25 Apr 2012 20:32:00 EDT. Please see our terms for use of feeds.

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NimbleTV streams cable content to 'any' device, launching 'in the next few months'

With services like Aereo TV taking a similar streaming approach -- and getting sued in the process -- NimbleTV won't have an easy road ahead, but the outfit's willing to take its chances. The startup plans to launch its subscription-based offering to the public within the next few months, allowing future users to stream cable content to unspecified devices at any time and from anywhere on the globe -- all thanks to Nimble's cloud-based software. However, unlike some of its competitors, NimbleTV will give customers the ability to select channel packages based on personal preferences, though that'll depend heavily on the TV providers going along for the ride. While the service will only be available in the US and India at first, the company does plan a broader launch at some point in the future. No word yet on how pricing will play out, but there is a NYC-only beta (just as Aereo did) which you can join now by giving the source below a quick click.

Continue reading NimbleTV streams cable content to 'any' device, launching 'in the next few months'

NimbleTV streams cable content to 'any' device, launching 'in the next few months' originally appeared on Engadget on Tue, 24 Apr 2012 07:16:00 EDT. Please see our terms for use of feeds.

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Netflix brought into the Sony Entertainment Network fold for British Bravia buffs

Britons and citizens of the ROI! Sony's bringing Netflix to all Sony Entertainment Network-connected devices. It looks like Kaz Hirai's plan to "unify" the company and its media offerings is beginning to gain a little momentum. If you have a SEN-connected 2012 Bravia TV or Blu-ray player, then the app should be available soon -- although no-one seems to know precisely when. If you're on PS3, or in the States, then Netflix is old news, so don't bother with the press release after the break

Continue reading Netflix brought into the Sony Entertainment Network fold for British Bravia buffs

Netflix brought into the Sony Entertainment Network fold for British Bravia buffs originally appeared on Engadget on Wed, 25 Apr 2012 06:31:00 EDT. Please see our terms for use of feeds.

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James Franco Teases Screen Time With Rihanna

Actor reveals he almost co-starred in 'We Found Love' clip and may appear with Ri in new Seth Rogen film.
By Jocelyn Vena, with reporting by Josh Horowitz

James Franco
Photo: Neilson Barnard/ Getty Images

James Franco recently made headlines when he posted a video of himself singing Rihanna's Dr. Luke joint "You Da One" on the Internet. The clip was short, sweet and a bit out of nowhere.

But if you think that Franco was in one of his performance-art moments when he created the viral video, think again. It turns out he's just a fan of the colorful singer. "[It] didn't take a lot of work [to lip-synch to her song]," he confessed to MTV News at CinemaCon in Las Vegas on Tuesday. "But I do like Rihanna."

In fact, his biggest confession about his connection to the singer came next. It seems the two were thisclose to working together on her 2011 "We Found Love" video. As the story goes, before male model Dudley O'Shaughnessy landed the role as Ri's troubled leading man, Franco had the opportunity to be cast as one-half of that rocky romance.

"She actually asked me to be in that video, the one with the relationship that gets crazy," he dished. "I couldn't do it. But, I guess, I hope that that means there's mutual love between us."

Well, apparently these two are getting a second chance to work together, and this time it's on the big screen. Franco teased that Rihanna may appear in pal Seth Rogen's flick "The Apocalypse," which follows a slew of celebs playing themselves. They're partying at Franco's house when they learn the apocalypse is coming.

"I think she's gonna be in the new movie that I'm doing, Seth Rogen's directorial debut," he shared. "I think she has a little part in that."

For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.

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Common environmental contaminant, cadmium, linked to rapid breast cancer cell growth

ScienceDaily (Apr. 23, 2012) ? Studies by researchers at Dominican University of California show that breast cancer cells become increasingly aggressive the longer they are exposed to small concentrations of cadmium, a heavy metal commonly found in cosmetics, food, water and air particles.

The study by Maggie Louie, associate professor of biochemistry, shows exposure to cadmium for prolonged periods of time can cause the progression of breast cancer to become more aggressive. Her findings were presented April 23, at the annual meeting of the American Society for Biochemistry and Molecular Biology, held in conjunction with the Experimental Biology 2012 conference in San Diego.

Breast cancer results from the abnormal growth of the cells in the mammary gland. The normal growth of mammary gland epithelial cells is modulated by the circulating levels of estrogen, a hormone produced by the ovaries. The activity of estrogen is stimulated by the estrogen receptor (ER). Heavy metals such as cadmium can act as endocrine disruptors and mimic estrogen, thereby disrupting the hormone dependent pathways.

While other studies have shown links between acute cadmium exposure and activation of the ER, Louie's study is one of few to focus on chronic cadmium exposure. "The relationship between cancer and chronic exposures at low levels is important to understand because most people are not exposed to high levels of heavy metals, unless they work in manufacturing plants that deal with such metals," Louie said.

She continued: "Unfortunately, cadmium is all around us -- it is in our food, our water, our makeup and our air. Understanding the role that cadmium plays in the progression of breast cancer is extremely important in order to find better ways to prevent the disease from advancing. Ninety percent of cancer deaths are associated with the cancer spreading to other parts of the body. If we can prevent the tumor from spreading, we have a better chance of treating cancer."

Taken together, the findings of Louie's new study and a handful of others published in recent years show that cadmium plays a significant role in the development of breast cancer. However, Louie's research is unique in that it focuses on prolonged exposure rather than acute exposure at the cellular level. The study indicates that chronic exposure to cadmium can contribute to the development of more malignant characteristics in breast cancer cells.

"Many of us are exposed to very low levels of cadmium from the environment on a daily basis, and our research shows that even small concentrations of this metal at prolonged exposures can cause breast cancer cell growth."

Cadmium is produced mainly as a byproduct from mining, smelting and refining sulfidic ores of zinc, lead and copper. Rocks mined to produce phosphate fertilizers also contain varying amounts of cadmium. Cadmium also is found in rechargeable batteries and cigarette smoke. Cadmium enters the body through consumption of contaminated food, water or inhalation of cigarette smoke.

Louie's preliminary data show an increase in the ability of breast cancer cells to migrate and invade through the extracellular matrix with prolonged cadmium exposure. The extracellular matrix is the outer barrier of an organ or tissue. Increased invasive and migration abilities are characteristic of cancer cells' ability to spread. Louie discovered that MCF-7 cells chronically exposed to cadmium express higher levels of SDF-1, a protein associated with tumor invasion and metastasis.

How specific proteins, including SDF-1, contribute to the aggressive characteristics of the cadmium exposed cells requires further research, and understanding their role in cadmium-induced carcinogenesis will provide further insights to how heavy metals contribute to breast cancer progression.

Louie's research is funded by the National Cancer Institute at the National Institutes of Health.

About the presentation Abstract No. 7038, "Chronic Exposure to Cadmium Increases in the Metastatic Phenotype of Breast Cancer Cells"; first author, Esmeralda Ponce, graduate student; Program No. 782.10; Poster Board No A291

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